Extended follow-up after anterior temporal lobectomy demonstrates seizure recurrence 20+ years postsurgery.

ABSTRACT:

Objective

Anterior temporal lobectomy (ATL) for medication-resistant localized epilepsy results in ablation or reduction of seizures for most patients. However, some individuals who attain an initial extended period of postsurgical seizure freedom will experience a later seizure recurrence. In this study, we examined the prevalence and some risk factors for late recurrence in an ATL cohort with extensive regular follow-up.

Methods

Included were 449 patients who underwent ATL at Austin Health, Australia, from 1978 to 2008. Postsurgical follow-up was undertaken 2-3 yearly. Seizure recurrence was tested using Kaplan-Meier analysis, log-rank test, and Cox regression. Late recurrence was qualified as a first disabling seizure >2 years postsurgery. We examined risks within the ATL

SUBMITTER: McIntosh AM 

PROVIDER: S-EPMC10098858 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature