Removing race and body surface area indexation for estimated kidney function based drug dosing: Aminoglycosides as justification of these principles.

ABSTRACT:

Study objective

The use of race in medicine can contribute to health inequity. Updated equations for estimated glomerular filtration rate (eGFR) without race have been published. Likewise, de-indexation of eGFR to body surface area (BSA) has been recommended by regulatory guidance for drug dosing in renal impairment. Clinical data justifying these recommendations for drug dosing are sparse. We examined the gain or loss of precision in drug dosing with estimated creatinine clearance (eCLcr) and eGFR using serum creatinine (eGFRcr) with and without race and BSA indexation by evaluating the population pharmacokinetics of the aminoglycosides as a classic drug class to probe kidney function.

Design

Medical records from adult patients treated with gentamicin or tobramycin over a 1

SUBMITTER: Pai MP 

PROVIDER: S-EPMC10098929 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature