Area under the curve: Comparing the value of factor VIII replacement therapies in haemophilia A.

ABSTRACT:

Introduction

In factor VIII (FVIII) prophylaxis for haemophilia A, cost comparisons have used price per international unit (IU) based on the once reasonable assumption of equivalent outcome per IU. Now, with several extended half-life (EHL) products available, new outcome-oriented ways to compare products are needed. Area under the curve (AUC) quantifies FVIII levels over time after infusion providing comparable data.

Aim

To develop a decision analytical model for making indirect comparisons of FVIII replacement products based on AUC.

Methods

A literature search identified 11 crossover studies with relevant pharmacokinetic data. A common comparator FVIII level curve was calculated using pooled data from selected studies. Absolute curves for other products were estimat

SUBMITTER: Persson S 

PROVIDER: S-EPMC10098947 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature