Efficacy and Safety of Upadacitinib Treatment in Adolescents With Moderate-to-Severe Atopic Dermatitis: Analysis of the Measure Up 1, Measure Up 2, and AD Up Randomized Clinical Trials.

ABSTRACT:

Importance

Atopic dermatitis onset usually occurs in childhood. Persistence of disease into adolescence and adulthood is common. It is important to evaluate new treatment options in adolescents because of the high unmet need in this population.

Objective

To assess the efficacy and safety of upadacitinib to treat moderate-to-severe atopic dermatitis in adolescents.

Design, setting, and participants

Prespecified analysis of adolescents enrolled in 3 randomized, double-blind, placebo-controlled phase 3 clinical trials in more than 20 countries across Europe, North and South America, Oceania, the Middle East, and the Asia-Pacific region from July 2018 through December 2020. Participants were adolescents aged 12 to 17 years with moderate-to-severe atopic dermatitis. Data a

SUBMITTER: Paller AS 

PROVIDER: S-EPMC10099102 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature