Dendrobium officinale aqueous extract influences the immune response following vaccination against SARS-CoV-2.

ABSTRACT:

Background

Vaccination is the most effective way to prevent coronavirus disease 2019 (COVID-19). However, it is often less protective and does not significantly increase antibody levels, especially in individuals with impaired immune systems. Nevertheless, the immunocompetence can be enhanced using a natural immunomodulator, such as Dendrobium officinale aqueous extract (DoAE).

Methods

To determine whether DoAE promotes antibody production, we treated healthy volunteers with DoAE during COVID-19 vaccination. Meanwhile, the control volunteers were given a placebo (cornstarch) during the vaccination. Antibody levels were measured at three-week intervals in the DoAE and control groups.

Results

DoAE enhanced immunity and preserved immune cell homeostasis. However, the neu

SUBMITTER: Gao X 

PROVIDER: S-EPMC10099150 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature