Comprehensive Cardiovascular Magnetic Resonance Tissue Characterization and Cardiotoxicity in Women With Breast Cancer.

ABSTRACT:

Importance

There is a growing interest in understanding whether cardiovascular magnetic resonance (CMR) myocardial tissue characterization helps identify risk of cancer therapy-related cardiac dysfunction (CTRCD).

Objective

To describe changes in CMR tissue biomarkers during breast cancer therapy and their association with CTRCD.

Design, setting, and participants

This was a prospective, multicenter, cohort study of women with ERBB2 (formerly HER2)-positive breast cancer (stages I-III) who were scheduled to receive anthracycline and trastuzumab therapy with/without adjuvant radiotherapy and surgery. From November 7, 2013, to January 16, 2019, participants were recruited from 3 University of Toronto-affiliated hospitals. Data were analyzed from July 2021 to June 2022.

SUBMITTER: Thavendiranathan P 

PROVIDER: S-EPMC10099158 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature