Expression of the pleiotrophin-midkine axis in a sheep tooth socket model of bone healing.

ABSTRACT:

Objective and background

Resorption of alveolar bone after tooth extraction is a common problem often requiring bone grafting. The success of the grafting procedures is dependent on multiple factors including the presence of growth factors. This is the first in vivo study to investigate the role of the pleiotrophin family of cytokines in alveolar bone regeneration. This research investigated the role of the pleiotrophin-midkine (PTN-MDK) axis during osteogenesis, with and without a grafting material, after tooth extraction in a sheep model.

Methods

Thirty Romney-cross ewes were anesthetized, and all premolar teeth on the right side were extracted. The sockets were randomized to controls sites with no treatment and test sites with Bio-Oss® graft material and Bio-Gide® membran

SUBMITTER: Nobakht S 

PROVIDER: S-EPMC10099163 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature