Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans.

ABSTRACT:

Context

Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown.

Objective

This work aimed to test how serum sOb-R is influenced by glucose, insulin, body fat, body mass index (BMI), food intake, and physical activity.

Methods

We performed an epidemiological triangulation combining cross-sectional, interventional, and Mendelian randomization study designs. In 5 independent clinical studies (n = 24-823), sOb-R was quantified in serum or plasma by commercial enzyme-linked immunosorbent assay kits using monoclonal antibodies. We performed mixed-model regression and 2-sample Mendelian randomization.

Results

In pooled, cross-sectional data, leveling b

SUBMITTER: Sommer C 

PROVIDER: S-EPMC10099165 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature