Graves Disease and Inflammatory Bowel Disease: A Bidirectional Mendelian Randomization.

ABSTRACT:

Context

Both Graves disease (GD) and inflammatory bowel disease (IBD) are common autoimmune diseases that severely damage a patient's quality of life. Previous epidemiological studies have suggested associations between GD and IBD. However, whether a causal relationship exists between these 2 diseases remains unknown.

Objective

To infer a causal relationship between GD and IBD using bidirectional 2-sample Mendelian randomization (MR).

Methods

We performed bidirectional 2-sample MR to infer a causal relationship between GD and IBD using genome-wide association study summary data obtained from Biobank Japan and the International Inflammatory Bowel Disease Genetic Consortium. Several methods (random-effect inverse variance weighted, weighted median, MR-Egger regression,

SUBMITTER: Xian W 

PROVIDER: S-EPMC10099169 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature