Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation.

ABSTRACT:

Background

Atrial Fibrillation (AF) is the most common sustained tachi-arrhythmia. Thrombus formation in the left atrial appendage (LAA) increases the risk of stroke and systemic embolism in patients with AF.

Objectives

The aim of this study was to compare thrombin generation in the LAA to the LA among patients with AF.

Methods

A cross-sectional study of consecutive patients with AF undergoing pulmonary veins catheter ablation. Blood samples from the femoral vein (FV), right atrium (RA), left atrium (LA), and LAA were collected during the catheter ablation procedures. Thrombin generation was assessed by a Calibrated Automated Thrombogram. The LAA-calibrated automated thrombogram parameters were compared with the RA, LA, and FV.

Results

A total of 47 consecutive

SUBMITTER: Elias A 

PROVIDER: S-EPMC10099305 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature