Neutrophils in lung cancer patients: Activation potential and neutrophil extracellular trap formation.

ABSTRACT:

Background

Patients with cancer have an increased risk of developing venous thromboembolism. Neutrophils and neutrophil extracellular traps (NETs) reportedly influence the risk of cancer-associated thrombosis. Subpopulations of high and low-density neutrophils (HDN/LDN) are of specific interest, as they might have different functions in cancer patients.

Objectives

We aimed to investigate differences between HDNs and LDNs of patients with lung cancer and healthy controls, and their ability of activation and NET formation.

Methods

Within the framework of the Vienna Cancer and Thrombosis Study, a prospective observational cohort study, HDNs and LDNs from 20 patients with lung cancer and 20 controls were isolated by density gradient centrifugation. The ability of neutroph

SUBMITTER: Mauracher LM 

PROVIDER: S-EPMC10099311 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature