Exercise-induced changes to the human gut microbiota and implications for colorectal cancer: a narrative review.

ABSTRACT: Physical activity is associated with reduced risks of colorectal cancer (CRC) incidence, recurrence and mortality. While these findings are consistent, the mechanism/s underlying this association remain unclear. Growing evidence supports the many ways in which differing characteristics of the gut microbiota can be tumourigenic or protective against CRC. CRC is characterised by significant dysbiosis including reduced short chain fatty acid-producing bacteria. Recent findings suggest that exercise can modify the gut microbiota, and these changes are inverse to the changes seen with CRC; however, this exercise-microbiota interaction is currently understudied in CRC. This review summarises parallel areas of research that are rapidly developing: The exercise-gut microbiota research and cancer-g

SUBMITTER: Boytar AN 

PROVIDER: S-EPMC10099575 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature