Genome-wide analysis of circular RNA-mediated ceRNA regulation in porcine skeletal muscle development.

ABSTRACT:

Background

As a diverse and abundant class of endogenous RNAs, circular RNAs (circRNAs) participate in various biological processes including cell proliferation and apoptosis. Nevertheless, few researchers have investigated the role of circRNAs in muscle development in cultivated pigs.

Results

In this study, we used RNA-seq to construct circRNA expression profiles in skeletal muscle of Jinfen White pigs at the age of 1, 90, and 180 days. Among the 16,990 identified circRNAs, 584 circRNAs were differentially expressed. Moreover, the enrichment analysis of DE circRNA host genes showed that they were mainly involved in muscle contraction, muscle organ development and muscle system processes, as well as AMPK and cAMP-related signal pathways. We also constructed a circRNA-miRNA-m

SUBMITTER: Yun J 

PROVIDER: S-EPMC10099641 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature