Synaptic Loss in Frontotemporal Dementia Revealed by [¹¹ C]UCB-J Positron Emission Tomography.

ABSTRACT:

Objective

Synaptic loss is an early feature of neurodegenerative disease models, and is severe in post mortem clinical studies, including frontotemporal dementia. Positron emission tomography (PET) with radiotracers that bind to synaptic vesicle glycoprotein 2A enables quantification of synaptic density in vivo. This study used [¹¹ C]UCB-J PET in participants with behavioral variant frontotemporal dementia (bvFTD), testing the hypothesis that synaptic loss is severe and related to clinical severity.

Methods

Eleven participants with clinically probable bvFTD and 25 age- and sex-matched healthy controls were included. Participants underwent dynamic [¹¹ C]UCB-J PET, structural magnetic resonance imaging, and a neuropsychological battery, including the revi

SUBMITTER: Malpetti M 

PROVIDER: S-EPMC10099663 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature