Propofol and survival: an updated meta-analysis of randomized clinical trials.

ABSTRACT:

Background

Propofol is one of the most widely used hypnotic agents in the world. Nonetheless, propofol might have detrimental effects on clinically relevant outcomes, possibly due to inhibition of other interventions' organ protective properties. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate if propofol reduced survival compared to any other hypnotic agent in any clinical setting.

Methods

We searched eligible studies in PubMed, Google Scholar, and the Cochrane Register of Clinical Trials. The following inclusion criteria were used: random treatment allocation and comparison between propofol and any comparator in any clinical setting. The primary outcome was mortality at the longest follow-up available. We conducted a fixed-eff

SUBMITTER: Kotani Y 

PROVIDER: S-EPMC10099692 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature