Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment.

ABSTRACT:

Background

Obesity and neurodevelopmental delay are complex traits that often co-occur and differ between boys and girls. Prenatal exposures are believed to influence children's obesity, but it is unknown whether exposures of pregnant mothers can confer a different risk of obesity between sexes, and whether they can affect neurodevelopment.

Methods

We analyzed data from 1044 children from the HELIX project, comprising 93 exposures during pregnancy, and clinical, neuropsychological, and methylation data during childhood (5-11 years). Using exposome-wide interaction analyses, we identified prenatal exposures with the highest sexual dimorphism in obesity risk, which were used to create a multiexposure profile. We applied causal random forest to classify individuals into two env

SUBMITTER: Caceres A 

PROVIDER: S-EPMC10099694 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature