Splicing complexity as a pivotal feature of alternative exons in mammalian species.

ABSTRACT:

Background

As a significant process of post-transcriptional gene expression regulation in eukaryotic cells, alternative splicing (AS) of exons greatly contributes to the complexity of the transcriptome and indirectly enriches the protein repertoires. A large number of studies have focused on the splicing inclusion of alternative exons and have revealed the roles of AS in organ development and maturation. Notably, AS takes place through a change in the relative abundance of the transcript isoforms produced by a single gene, meaning that exons can have complex splicing patterns. However, the commonly used percent spliced-in (Ψ) values only define the usage rate of exons, but lose information about the complexity of exons' linkage pattern. To date, the extent and functional consequenc

SUBMITTER: Zhao F 

PROVIDER: S-EPMC10099729 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature