Prepregnancy exposure to dietary arsenic and congenital heart defects.

ABSTRACT:

Introduction

Arsenic crosses the placenta and accumulates in fetal tissues. In the United States, diet is the predominant route of arsenic exposure, but epidemiologic data are sparse regarding this exposure and development of birth defects. Using data from a large case-control study, we explored associations between maternal dietary arsenic exposure and congenital heart defects (CHDs), the most prevalent birth defects.

Methods

We used maternal self-reported dietary assessments and arsenic concentration estimates in food items to estimate average daily exposure to dietary arsenic during the year before pregnancy for mothers of 10,446 unaffected control children and 6,483 case children diagnosed with CHDs. Using tertiles of dietary exposure to total arsenic (all species) and i

SUBMITTER: Suhl J 

PROVIDER: S-EPMC10099864 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature