Treatment-related adverse events of antibody-drug conjugates in clinical trials: A systematic review and meta-analysis.

ABSTRACT:

Background

Antibody-drug conjugates (ADCs) have complex molecular structures and have been tested in numerous clinical trials. Therefore, understanding the mechanisms of their toxicity when applied in medical practice is of high importance.

Methods

In a systematic review and meta-analysis of data gathered from different scientific databases (PubMed, Embase, Cochrane, and Web of Science) between January 1, 2000, and June 7, 2022, the authors applied a random-effects model with logit transformation and evaluated the heterogeneity between studies using I² statistics. The primary outcome was the incidence and 95% confidence interval (CI) for all-grade and grade ≥3 treatment-related adverse events and differences between different drugs, molecular structures, and cance

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10099922 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature