Application of amniotic membranes in reconstructive surgery of internal organs-A systematic review and meta-analysis.

ABSTRACT: Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta-analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic search was performed in MEDLINE-PubMed database and OVID Embase to retrieve human and controlled animal studies on wound closure of internal organs. The Cochrane Risk of Bias tool for randomized clinical trials and the SYRCLE risk of bias tool for animal studies were used. Meta-analyses (MAs) were conducted for controlled animal studies to assess efficacy of closure, mortality and complicatio

SUBMITTER: Maljaars LP 

PROVIDER: S-EPMC10099938 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature