Glycaemic control for patients with severe acute brain injury: Protocol for a systematic review.

ABSTRACT:

Background

Hyperglycaemia is common in patients with acute brain injury admitted to an intensive care unit (ICU). Many studies have found associations between development of hyperglycaemia and increased mortality in hospitalised patients. However, the optimal target for blood glucose control is unknown. We want to conduct a systematic review with meta-analysis and trial sequential analysis to explore the beneficial and harmful effects of restrictive versus liberal glucose control on patient outcomes in adults with severe acute brain injury.

Methods

We will systematically search medical databases including CENTRAL, Embase, MEDLINE and trial registries. We will search the following websites for ongoing or unpublished trials: http://www.controlled-trials.com/, http://www.

Cl

SUBMITTER: Fenger AW 

PROVIDER: S-EPMC10099998 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature