Acetaminophen pharmacokinetics in infants and children with congenital heart disease.

ABSTRACT:

Background

Acetaminophen is routinely used for perioperative analgesia in children undergoing major surgical procedures. There are few estimates of acetaminophen pharmacokinetic parameters in children with congenital heart disease, especially those with cyanotic heart disease.

Aims

The current study prospectively investigated differences in acetaminophen pharmacokinetics following surgery using cardiopulmonary bypass in children with cyanotic and acyanotic congenital heart disease.

Methods

Children (2-6 years, 9-23 kg) presenting for median sternotomy for Fontan palliation (cyanotic patients) or two ventricle surgical repair (acyanotic patients) were eligible for inclusion. A single intravenous dose of acetaminophen (15 mg/kg) was administered at the start of sternal

SUBMITTER: Holladay J 

PROVIDER: S-EPMC10100048 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature