Escherichia cryptic clade I is an emerging source of human intestinal pathogens.

ABSTRACT:

Background

Within the genus Escherichia, several monophyletic clades other than the traditionally defined species have been identified. Of these, cryptic clade I (C-I) appears to represent a subspecies of E. coli, but due to the difficulty in distinguishing it from E. coli sensu stricto, the population structure and virulence potential of C-I are unclear.

Results

We defined a set of true C-I strains (n = 465), including a Shiga toxin 2a (Stx2a)-producing isolate from a patient with bloody diarrhoea identified by the retrospective analyses using a C-I-specific detection system. Through genomic analysis of 804 isolates from the cryptic clades, including these C-I strains, we revealed their global population structures and the marked accumulation of virulence genes and antimicr

SUBMITTER: Okuno M 

PROVIDER: S-EPMC10100065 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature