VSSP-activated macrophages mediate senescence and tumor inhibition in a preclinical model of advanced prostate cancer.

ABSTRACT: Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castration-resistant prostate cancer (CRPC). For this reason, the identification of novel effective therapies for treating CRPC is needed. Immunotherapeutic strategies focused on macrophages as antitumor effectors, directly enhancing their tumoricidal potential at the tumor microenvironment or their adoptive transfer after ex vivo activation, have arisen as promising therapies in several cancer types. Despite several approaches centered on the activation of tumor-associated macrophages (TAMs) in PCa are under investigation, to date there is no evidence of clinical benefit in patients. In addition,

SUBMITTER: Alvarez-Arzola R 

PROVIDER: S-EPMC10100133 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature