Neutrophil β₁ adrenoceptor blockade blunts stroke-associated neuroinflammation.

ABSTRACT:

Background and purpose

Reperfusion therapy is the standard of care for ischaemic stroke; however, there is a need to identify new therapeutic targets able to ameliorate cerebral damage. Neutrophil β₁ adrenoceptors (β1AR) have been linked to neutrophil migration during exacerbated inflammation. Given the central role of neutrophils in cerebral damage during stroke, we hypothesize that β1AR blockade will improve stroke outcomes.

Experimental approach

Rats were subjected to middle cerebral artery occlusion-reperfusion to evaluate the effect on stroke of the selective β1AR blocker metoprolol (12.5 mg·kg^-1 ) when injected i.v. 10 min before reperfusion.

Key results

Magnetic resonance imaging and histopathology analysis showed that pre-reperfusion i.v.

SUBMITTER: Clemente-Moragon A 

PROVIDER: S-EPMC10100149 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature