Long-term effects of prophylactic MgSO₄ in maternal immune activation rodent model at adolescence and adulthood.

ABSTRACT: The effects of MgSO₄ as an anti-inflammatory agent in pregnant women have been investigated in the last few years. Infections can cause an inflammatory reaction involving the placenta membranes and amniotic cavity. They may have short-term effects on the mother and her fetuses, like preterm birth, cerebral palsy, and developmental delay. Despite the alleged advantages of MgSO₄ as a neuroprotective agent in the preterm brain, the long-term molecular and behavioral function of MgSO₄ has not been fully elucidated. Here, we investigated the long-term effect of antenatal MgSO₄ , during late gestation, on offspring's behavior focusing on cognitive function, motor activity, and social cognition in adolescence and adulthood, and explored its influence on

SUBMITTER: Dabbah-Assadi F 

PROVIDER: S-EPMC10100175 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature