Promoter evolution of mammalian gene duplicates.

ABSTRACT:

Background

Gene duplication is thought to be a central process in evolution to gain new functions. The factors that dictate gene retention following duplication as well paralog gene divergence in sequence, expression and function have been extensively studied. However, relatively little is known about the evolution of promoter regions of gene duplicates and how they influence gene duplicate divergence. Here, we focus on promoters of paralog genes, comparing their similarity in sequence, in the sets of transcription factors (TFs) that bind them, and in their overall promoter architecture.

Results

We observe that promoters of recent duplications display higher sequence similarity between them and that sequence similarity rapidly declines between promoters of more ancient paral

SUBMITTER: Fraimovitch E 

PROVIDER: S-EPMC10100218 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature