Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGF-β₁ signaling.

ABSTRACT: Autosomal dominant polycystic kidney disease (PKD) is a hereditary kidney disorder which can affect cardiovascular system. Cardiac hypertrophy and cardiomyopathy in PKD have been reported by echocardiography analyses, but histopathology analyses of human PKD hearts have never been examined. The current studies evaluated human heart tissues from five subjects without PKD (non-PKD) and five subjects with PKD. Our histopathology data of human PKD hearts showed an increased extracellular matrix associated with cardiac hypertrophy and fibrosis. Hypertrophy- and fibrosis-associated pathways involving abnormal cardiac structure were next analyzed. We found that human PKD myocardium was infiltrated by inflammatory macrophage M1 and M2; expression of transforming growth factor (TGF-β₁) a

SUBMITTER: Amirrad F 

PROVIDER: S-EPMC10100231 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature