Identification of novel cell-free RNAs in maternal plasma as preterm biomarkers in combination with placental RNA profiles.

ABSTRACT:

Background

Preterm birth (PTB) is the main driver of newborn deaths. The identification of pregnancies at risk of PTB remains challenging, as the incomplete understanding of molecular mechanisms associated with PTB. Although several transcriptome studies have been done on the placenta and plasma from PTB women, a comprehensive description of the RNA profiles from plasma and placenta associated with PTB remains lacking.

Methods

Candidate markers with consistent trends in the placenta and plasma were identified by implementing differential expression analysis using placental tissue and maternal plasma RNA-seq datasets, and then validated by RT-qPCR in an independent cohort. In combination with bioinformatics analysis tools, we set up two protein-protein interaction networks of

SUBMITTER: Jin H 

PROVIDER: S-EPMC10100253 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature