Effect of Trikafta on bone density, body composition and exercise capacity in CF: A pilot study.

ABSTRACT:

Background

While the positive effect of Trikafta on cystic fibrosis (CF) pulmonary disease is well established, there is limited data about its effect on bone mineral density (BMD), body composition and exercise capacity.

Methods

A pilot single center study. BMD and body composition were measured three months after the initiation of Trikafta (study group) and compared to values obtained 2 years earlier. CF patients not treated with Trikafta, for whom BMD was measured 2 years apart, served as controls. Spirometry, lung clearance index (LCI), sweat test, six-min walk test (6MWT) and cardio-pulmonary exercise test (CPET) were performed before and three months after the initiation of Trikafta.

Results

Nine study patients, aged 18.6 ± 4.7 years, and nine controls. For the

SUBMITTER: Gur M 

PROVIDER: S-EPMC10100338 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature