Effects of altered salt intake and diet on cytokines in humans: A 20-week randomized cross-over intervention study.

ABSTRACT: High sodium concentration alters leukocyte activation, and in particular T-helper (Th) lymphocyte polarization, and drives the development of autoimmune diseases in mouse studies. Similar results have been obtained with human leukocytes under in vitro settings and in few observational studies. Therefore, salt has been implicated as a risk factor for autoimmune diseases. Here, we examined whether physiologically relevant changes in salt intake or diet alter cytokine concentrations. In a 20-wk double-blinded, placebo-controlled study 106 participants were randomized to Habitual and Healthy Nordic diets, and further to Usual Sodium and Reduced Sodium intake groups using a cross-over setup. Plasma concentrations of 45 cytokines were measured at three different time-points using a multiplex ass

SUBMITTER: Niiranen T 

PROVIDER: S-EPMC10100453 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature