A reliable quantitative method for determining CBD content and release from transdermal patches in Franz cells.

ABSTRACT:

Introduction

There are several cannabidiol (CBD) transdermal patches available on the market. However, none are FDA-approved. Furthermore, not much evidence has been published about CBD release and skin permeation from such patches, so the effectiveness and reliability remain unclear.

Objectives

We aimed to develop a method to determine the in vitro release and skin permeation of CBD from transdermal patches using Franz cell diffusion in combination with quantitative ¹ H-NMR (qNMR).

Materials and methods

The study was conducted on CBD patches with known CBD content and six different commercially available or market-ready CBD patches using a Franz cell with a Strat-M™ membrane and with samples taken directly from the transdermal patch for qNMR analysis.

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SUBMITTER: Yu L 

PROVIDER: S-EPMC10100468 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature