Microglia and astrocyte activation is region-dependent in the α-synuclein mouse model of Parkinson's disease.

ABSTRACT: Inflammation is a common feature in neurodegenerative diseases that contributes to neuronal loss. Previously, we demonstrated that the basal inflammatory tone differed between brain regions and, consequently, the reaction generated to a pro-inflammatory stimulus was different. In this study, we assessed the innate immune reaction in the midbrain and in the striatum using an experimental model of Parkinson's disease. An adeno-associated virus serotype 9 expressing the α-synuclein and mCherry genes or the mCherry gene was administered into the substantia nigra. Myeloid cells (CD11b⁺ ) and astrocytes (ACSA2⁺ ) were purified from the midbrain and striatum for bulk RNA sequencing. In the parkinsonian midbrain, CD11b⁺ cells presented a unique anti-inflammatory tr

SUBMITTER: Basurco L 

PROVIDER: S-EPMC10100513 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature