Glial progenitor cells of the adult human white and grey matter are contextually distinct.
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ABSTRACT:
SUBMITTER: Osorio MJ
PROVIDER: S-EPMC10100527 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Glial progenitor cells of the adult human white and grey matter are contextually distinct.
Osorio Maria Joana MJ Mariani John N JN Zou Lisa L Schanz Steven J SJ Heffernan Kate K Cornwell Adam A Goldman Steven A SA
Glia 20221105 3
Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of human grey and white brain matter are distinct in their architecture and associated gene expression. RNA profiling of NG2-defined hGPCs derived from adult human neocortex and white matter differed in their expression of genes involved in Wnt, NOTCH, BMP and TGFβ signaling, suggesting compartment-selective biases in fate and ...[more]
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