Local Temperature Increments and Induced Cell Death in Intracellular Magnetic Hyperthermia.

ABSTRACT: The generation of temperature gradients on nanoparticles heated externally by a magnetic field is crucially important in magnetic hyperthermia therapy. But the intrinsic low heating power of magnetic nanoparticles, at the conditions allowed for human use, is a limitation that restricts the general implementation of the technique. A promising alternative is local intracellular hyperthermia, whereby cell death (by apoptosis, necroptosis, or other mechanisms) is attained by small amounts of heat generated at thermosensitive intracellular sites. However, the few experiments conducted on the temperature determination of magnetic nanoparticles have found temperature increments that are much higher than the theoretical predictions, thus supporting the local hyperthermia hypothesis. Reliable intra

SUBMITTER: Gu Y 

PROVIDER: S-EPMC10100554 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature