Large-Scale Detection of Telomeric Motif Sequences in Genomic Data Using TelFinder.

ABSTRACT: Telomeres are regions of tandem repeated sequences at the ends of linear chromosomes that protect against DNA damage and chromosome fusion. Telomeres are associated with senescence and cancers and have attracted the attention of an increasing number of researchers. However, few telomeric motif sequences are known. Given the mounting interest in telomeres, an efficient computational tool for the de novo detection of the telomeric motif sequence of new species is needed since experimental-based methods are costly in terms of time and effort. Here, we report the development of TelFinder, an easy-to-use and freely available tool for the de novo detection of telomeric motif sequences from genomic data. The vast quantity of readily available genomic data makes it possible to apply

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10100673 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature