Systemic Lupus Erythematosus May Be a Risk Factor for Antimalarial-Induced Retinopathy Compared With Other Rheumatologic Diseases.

ABSTRACT:

Objective

To describe the pattern and risk factors for antimalarial (AM)-induced retinopathy in patients with rheumatic diseases.

Methods

A retrospective chart review was conducted at an urban Canadian center for patients with AM use of more than 3 months and documented retinopathy screening. Univariate and multivariate regression analyses were performed to determine risk factors for retinopathy. Sensitivity analyses included stratification of analysis by method of screening and by hydroxychloroquine (HCQ) versus chloroquine (CQ).

Results

A total of 613 patients were included in the final analysis, with systemic lupus erythematosus (SLE) (n = 259) as the most common diagnosis. Definite AM-induced retinal toxicity was observed in 12 patients, 11 of whom had SLE. The ea

SUBMITTER: Liu HY 

PROVIDER: S-EPMC10100695 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature