The Sensory Histidine Kinase CusS of Escherichia coli Senses Periplasmic Copper Ions.

ABSTRACT: Two-component regulatory systems composed of a membrane-bound sensor/sensory histidine kinase (HK) and a cytoplasmic, DNA-binding response regulator (RR) are often associated with transenvelope efflux systems, which export transition metal cations from the periplasm directly out of the cell. Although much work has been done in this field, more evidence is needed for the hypothesis that the respective two-component regulatory systems are indeed sensing periplasmic ions. If so, a regulatory circuit between the concentration of periplasmic metal cations, sensing of these metals, and control of expression of the genes for transenvelope efflux systems that remove periplasmic cations can be assumed. Escherichia coli possesses only one transenvelope efflux system for metal cations, the Cus system

SUBMITTER: Rismondo J 

PROVIDER: S-EPMC10100754 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature