Cross-Talk and Multiple Control of Target of Rapamycin (TOR) in Sclerotinia sclerotiorum.

ABSTRACT: Sclerotinia sclerotiorum is a necrotrophic phytopathogenic fungus that cross-talks with its hosts for control of cell-death pathways for colonization. Target of rapamycin (TOR) is a central regulator that controls cell growth, intracellular metabolism, and stress responses in a variety of eukaryotes, but little is known about TOR signaling in S. sclerotiorum. In this study, we identified a conserved TOR signaling pathway and characterized SsTOR as a critical component of this pathway. Hyphal growth of S. sclerotiorum was retarded by silencing SsTOR, moreover, sclerotia and compound appressoria formation were severely disrupted. Notably, pathogenicity assays of strains shows that the virulence of the SsTOR-silenced strains were dramatically decreased. SsTOR was determined to p

SUBMITTER: Jiao W 

PROVIDER: S-EPMC10100786 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature