Survival of Bordetella bronchiseptica in Acanthamoeba castellanii.

ABSTRACT: The respiratory pathogenic bacterium Bordetella bronchiseptica can persistently survive in terrestrial and aquatic environments, providing a source of infection. However, the environmental lifestyle of the bacterium is poorly understood. In this study, expecting repeated encounters of the bacteria with environmental protists, we explored the interaction between B. bronchiseptica and a representative environmental amoeba, Acanthamoeba castellanii, and found that the bacteria resisted amoeba digestion and entered contractile vacuoles (CVs), which are intracellular compartments involved in osmoregulation, to escape amoeba cells. In prolonged coculture, A. castellanii supported the proliferation of B. bronchiseptica. The avirulent Bvg^- phase, but not the virulent Bvg⁺ pha

SUBMITTER: Nugraha DK 

PROVIDER: S-EPMC10100856 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature