Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence.

ABSTRACT: The number of patients suffering from fungal diseases has constantly increased during the last decade. Among the fungal pathogens, the airborne filamentous fungus Aspergillus fumigatus can cause chronic and fatal invasive mold infections. So far, only three major classes of drugs (polyenes, azoles, and echinocandins) are available for the treatment of life-threatening fungal infections, and all present pharmacological drawbacks (e.g., low solubility or toxicity). Meanwhile, clinical antifungal-resistant isolates are continuously emerging. Therefore, there is a high demand for novel antifungal drugs, preferentially those that act on new targets. We studied urease and the accessory proteins in A. fumigatus to determine their biochemical roles and their influence on virulence. Urease is cruci

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC10100864 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature