Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic.

ABSTRACT: During the coronavirus disease 2019 (COVID-19) pandemic, large differences in susceptibility and mortality due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported between populations in Europe and South Asia. While both host and environmental factors (including Mycobacterium bovis BCG vaccination) have been proposed to explain this, the potential biological substrate of these differences is unknown. We purified peripheral blood mononuclear cells from individuals living in India and the Netherlands at baseline and 10 to 12 weeks after BCG vaccination. We compared chromatin accessibility between the two populations at baseline, as well as gene transcription profiles and cytokine production capacities upon stimulation. The chromatin accessibility of ge

SUBMITTER: Geckin B 

PROVIDER: S-EPMC10100912 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature