α-Tocopherol Transfer Protein-Null Mice with Very Low α-Tocopherol Status Do Not Have an Enhanced Lipopolysaccharide-Induced Acute Inflammatory Response.

ABSTRACT:

Background

The α-tocopherol transfer protein-null (Ttpa^-/-) mouse model is a valuable tool for studying the molecular and functional consequences of vitamin E (α-tocopherol, αT) deficiency. Because αT has been associated with reduced oxidative stress and improved immune function, we hypothesized that depleted αT concentration would exacerbate LPS-induced acute inflammatory response in the brain and heart of Ttpa^-/- mice fed a vitamin E deficient (VED) diet.

Objectives

The objective was to investigate how extremely low αT status, followed by exposure to LPS, altered the acute inflammatory response to LPS in Ttpa^-/- and wild-type (Ttpa^+/+) mice.

Methods

Three-week-old mal

SUBMITTER: Hashida M 

PROVIDER: S-EPMC10100938 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature