Genomics of Invasive Cutibacterium acnes Isolates from Deep-Seated Infections.

ABSTRACT: Cutibacterium acnes, formerly known as Propionibacterium acnes, is a commensal of the human pilosebaceous unit but also causes deep-seated infection, especially in the context of orthopedic and neurosurgical foreign materials. Interestingly, little is known about the role of specific pathogenicity factors for infection establishment. Here, 86 infection-associated and 103 commensalism-associated isolates of C. acnes were collected from three independent microbiology laboratories. We sequenced the whole genomes of the isolates for genotyping and a genome-wide association study (GWAS). We found that C. acnes subsp. acnes IA₁ was the most significant phylotype among the infection isolates (48.3% of all infection isolates; odds ratio [OR] = 1.98 for infection). A

SUBMITTER: Both A 

PROVIDER: S-EPMC10100948 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature