Proteomic Study of the Interactions between Phages and the Bacterial Host Klebsiella pneumoniae.

ABSTRACT: Phages and bacteria have acquired resistance mechanisms for protection. In this context, the aims of the present study were to analyze the proteins isolated from 21 novel lytic phages of Klebsiella pneumoniae in search of defense mechanisms against bacteria and also to determine the infective capacity of the phages. A proteomic study was also conducted to investigate the defense mechanisms of two clinical isolates of K. pneumoniae infected by phages. For this purpose, the 21 lytic phages were sequenced and de novo assembled. The host range was determined in a collection of 47 clinical isolates of K. pneumoniae, revealing the variable infective capacity of the phages. Genome sequencing showed that all of the phages were lytic phages belonging to the order Caudovirales. Phage s

SUBMITTER: Bleriot I 

PROVIDER: S-EPMC10100988 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature