Limosilactobacillus fermentum Limits Candida glabrata Growth by Ergosterol Depletion.

ABSTRACT: Candida glabrata is a human-associated opportunistic fungal pathogen. It shares its niche with Lactobacillus spp. in the gastrointestinal and vaginal tract. In fact, Lactobacillus species are thought to competitively prevent Candida overgrowth. We investigated the molecular aspects of this antifungal effect by analyzing the interaction of C. glabrata strains with Limosilactobacillus fermentum. From a collection of clinical C. glabrata isolates, we identified strains with different sensitivities to L. fermentum in coculture. We analyzed the variation of their expression pattern to isolate the specific response to L. fermentum. C. glabrata-L. fermentum coculture induced genes associated with ergosterol biosynthesis, weak acid stress, and drug/chemica

SUBMITTER: Zangl I 

PROVIDER: S-EPMC10100998 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature