Sporulation Activated via σ^W Protects Bacillus from a Tse1 Peptidoglycan Hydrolase Type VI Secretion System Effector.

ABSTRACT: Within bacterial communities, community members engage in interactions employing diverse offensive and defensive tools to reach coexistence. Extracellular-matrix production and sporulation are defensive mechanisms used by Bacillus subtilis cells when they interact with Pseudomonas chlororaphis strains expressing a type VI secretion system (T6SS). Here, we define Tse1 as the main toxin mobilized by the Pseudomonas chlororaphis T6SS that triggers sporulation in Bacillus subtilis. We characterize Tse1 as a peptidoglycan hydrolase that indirectly alters the dynamics and functionality of the Bacillus cell membrane. We also delineate the response of Bacillus cells to Tse1, which through the coordinated actions of the extracellular sigma factor σ^W and the cytoplasmic hist

SUBMITTER: Perez-Lorente AI 

PROVIDER: S-EPMC10100999 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature