Mucin Protein of Aedes aegypti Interacts with Dengue Virus 2 and Influences Viral Infection.

ABSTRACT: Dengue, caused by dengue virus (DENV), is the most prevalent vector-borne viral disease, posing a serious health concern to 2.5 billion people worldwide. DENV is primarily transmitted among humans by its mosquito vector Aedes aegypti; hence, the identification of a novel dengue virus receptor in mosquitoes is critical for the development of new anti-mosquito measures. In the current study, we have identified peptides which potentially interact with the surface of the virion particles and facilitate virus infection and movement during their life cycle in the mosquito vector. To identify these candidate proteins, we performed phage-display library screening against domain III of the envelope protein (EDIII), which plays an essential role during host cell receptor binding for viral entry. The

SUBMITTER: Yadav K 

PROVIDER: S-EPMC10101019 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature