Endogenous IL-33 Accelerates Metacestode Growth during Late-Stage Alveolar Echinococcosis.

ABSTRACT: During the course of the infectious disease alveolar echinococcosis (AE), the larval stage of Echinococcus multilocularis develops in the liver, where an initial Th1/Th17 immune response may allow its elimination in resistant individuals. In patients susceptible to infection and disease, the Th2 response initiates later, inducing tolerance to the parasite. The role of interleukin 33 (IL-33), an alarmin released during necrosis and known to drive a Th2 immune response, has not yet been described during AE. Wild-type (WT) and IL-33^-/- C57BL/6J mice were infected by peritoneal inoculation with E. multilocularis metacestodes and euthanized 4 months later, and their immune response were analyzed. Immunofluorescence staining and IL-33 enzyme-linked immunosorbent assay (ELISA) were als

SUBMITTER: Autier B 

PROVIDER: S-EPMC10101030 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature