N⁶-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.

ABSTRACT: N⁶-methyladenosine (m⁶A) modification is a major RNA epigenetic regulatory mechanism. The dynamics of m⁶A levels in viral genomic RNA and their mRNAs have been shown to have either pro- or antiviral functions, and therefore, m⁶A modifications influence virus-host interactions. Currently, no reports are available on the effect of m⁶A modifications in the genome of Peste des petits ruminants virus (PPRV). In the present study, we took PPRV as a model for nonsegmented negative-sense single-stranded RNA viruses and elucidate the role of m⁶A modification on viral replication. We detected m⁶A-modified sites in the mRNA of the virus and host cells, as well as the PPRV RNA genome. Further, it was found that the lev

SUBMITTER: Khan O 

PROVIDER: S-EPMC10101086 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature